CELLine<sup>®</sup> Bioreactors

CELLine® Bioreactors

Multiuse Membrane Culture Flasks for Antibody and Protein Production.

In an effort to push science forward, WHEATON® has a new line of membrane driven flasks for high density cell culture. The flasks are designed to enhance small scale bio-production for antibody and protein generation. Conventional in vivo or in vitro cell culture methods can be laborious, may have low cell density and require significant purification. CELLine® flasks address these three areas of limitation observed in static tissue culture flasks.

Handling Requirements — CELLine® flasks reduce the handling requirement by requiring less consumable items and allowing longer run times due to their unique metabolite regulating upper membrane. This membrane allows for bulk media storage during operation to ensure constant and regulated nutrient access for the cells.

Cell Densities — CELLine® flasks ensure maximum gas exchange by placing the gas permeable lower membrane directly next to the cells.

This allows for optimal oxygen and carbon dioxide transfer for metabolising cells.

Purification — The upper and lower membranes form an optimized compartment for cell proliferation. This allows for the reduced use of growth factors and hormones and concentrates the antibody and proteins of interest.

Benefits of CELLine® Flask include:

  • Multiuse flask
  • High cell density and high product concentration
  • Reduces operation time
  • Decreases use of consumables
  • Cost-efficient, space saving, and stackable
  • No additional equipment required for operation
Product codeFlask typeCulture typeMedia (ml) compartment sizeCell (ml)compartment sizeCase quantity
WCL1000-1 CELLine 1000 Suspension 100 15 1
WCL1000-3 CELLine 1000 Suspension 1000 15 3
WCL1000AD-1 CELLine 1000-AD Adherent 1000 15 1
WCL1000AD-3 CELLine 1000-AD Adherent 1000 15 3
WCL0350-1 CELLine 350 Suspension 350 5 1
WCL0350-5 CELLine 350 Suspension 350 5 5

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